Domain names used in works of fiction have often been registered in the DNS, either by their creators or by cybersquatters attempting to profit from it. This phenomenon prompted NBC to purchase the domain name Hornymanatee.com after talk-show host Conan O'Brien spoke the name while ad-libbing on his show. O'Brien subsequently created a website based on the concept and used it as a running gag on the show.
Anyone can buy a domain name. To do so, you visit a domain name registrar, such as GoDaddy or Namecheap, key in the domain you want to buy, and pay a fee. You can't buy just any domain, of course—only one that isn't already registered by another person or business and that bears a valid domain suffix. In general, you'll want to buy something that is catchy and short so that it's both easy for people to remember, and easy for them to type in—like "PCMag," for example. That good search engine optimization (SEO) and it's also common sense. You might also want to do some research on key terms for your business. If you can get a good one into your site's name, that's all the better, from an SEO perspective.